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Effect of Seed Load on Crystallization Kinetics Based on Optical Method


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Effect of Seed Load on Crystallization Kinetics Based on Optical Method
HUANG De-chun12LIU Wei3WANG Zhi-xiang1SUN Yue-ming2
1.School of Pharmacy,China Pharmaceutical University,Nanjing 210009,China;2.School of Chemistry and Chemical Engineering,Southeast University,Nanjing 210096,China;3.Department of Mechanical Electronics Engineering,Nanjing Normal University,Nanjing 210042,
crystallization kinetics cooling transmittance crystal seeds nucleation crystal growth
To further investigate the effects of seed load on kinetics of solution crystallization,particularly crystal growth kinetics,the aqueous solution of potassium nitrate is selected and the relevant kinetic experiments of batch cooling crystallization with seed are carried out,in which the optical method is introduced and used.The curves of transmittance reflecting solid phase information are firstly determined,and the nucleation and crystal growth kinetics parameters are successfully estimated with the mass ratio and relative supersaturation data of solution using a mathematical model reported in our lab.Backward calculations with the help of the model parameters are performed,and the effects of seed load on nucleation and crystal growth kinetics are investigated and discussed in detail.The results show that the nucleation capacity decreases and crystal growth capacity increases with increasing seed load,and the size distribution of crystal products tends to become more uniform.With the increase of seed load,the linear growth rate of single crystal and the mean size of products are found reducing accordingly.


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Last Update: 2012-11-19