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Flow Design and Device Development of Supercritical Fluid Anti-solvent Crystallization


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Flow Design and Device Development of Supercritical Fluid Anti-solvent Crystallization
HUANG De-chun1LIU Wei2YUE Long1SHI Yi-qiang1WANG Zhi-xiang1
1.School of Pharmacy,China Pharmaceutical University,Nanjing 210009,China;2.Department of Mechanical Electronics Engineering,Nanjing Normal University,Nanjing 210042,China
supercritical fluid anti-solvent crystallization flow designs device development
To simplify the operation flow and drop the device building cost of supercritical fluid anti-solvent(SAS) crystallization,one of the newly emerging separation technologies in recent years,based on the investigation of supercritical extraction device development,a batch flow employing the supercritical CO2 as an anti-solvent is designed for the biochemical and antibiotic material treatments.A set of small scale device is built by combining with the reconstruction of pressure pump and the rational collocation of flow subsystems such as filter,pipeline and condensation.The building cost of the newly developed device is far lower than the international market quotation of similar apparatus.The experimental results of water pressure and SAS granulation of citric acid-acetone solution show that,the newly developed device has the characteristics of stable and rapid pressurization and reliable tightness,and its operating and controlling performance is also perfect.The change tendencies of the determined curves of production rate versus pressure and production rate versus temperature are found to be in good agreement with those reported in literature,namely that the production rate increases with the increase of pressure,and increases firstly and decreases later with the increase of temperature.


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Last Update: 2012-11-02