|Table of Contents|

Effects of Resveratrol Analogues on Proliferation and Apoptosis of Bel-7404 Cells

《南京理工大学学报》(自然科学版)[ISSN:1005-9830/CN:32-1397/N]

Issue:
2010年04期
Page:
565-569
Research Field:
Publishing date:

Info

Title:
Effects of Resveratrol Analogues on Proliferation and Apoptosis of Bel-7404 Cells
Author(s):
HAN Xue-lian12GAO Jun-feng3CHEN Jun-hao4
1.School of Chemical Engineering,NUST,Nanjing 210094,China;2.Jiangsu Research Institute of Safety Production Science,Nanjing 210042,China;3.Shanghai Qingsong Pharmaceutical Co.,Ltd.,Shanghai 201417,China;4.The Affiliated Drum Tower Hospital,Nanjing University Medical College,Nanjing 210008,China
Keywords:
resveratrol analogues hepatocellular carcinoma apoptosis Bcl-2 Bax
PACS:
R285
DOI:
-
Abstract:
In order to find a new anticancer-drug,a resveratrol analogue is synthesized with 3,4-dimethoxyphenyl-acetonitril and p-methoxybenzaldehyde,and the hepatocellular carcinoma Bel-7404 cells are treated with the resveratrol analogue.The treated sample are detected by MTT,Flow Cytometer,Hoechst 33258 Fluorescence Coloration and Western blot,in order to examine the influence of the analogue on the proliferation of the Bel-7404 cells and its mechanism.The results show the resveratrol analogue with methoxy can induce the decrease in the expression of Bcl-2 and the increase in the expression of Bax,stop cell cycle in G2/M,make the apoptosis happen and finally inhibit the proliferation of Bel-7404 cells.

References:

[ 1] ?? 张志伟. 应合理选择肝癌综合治疗方法[ J]. 肝胆 外科杂志, 2010, 18( 1) : 1- 2.
[ 2] 甄永苏, 邵荣光, 李电东, 等. 抗肿瘤药物研究与开 发[M ]. 北京: 化学工业出版社, 2004.
[ 3] Burns J, Yoko ta T, Ash ihara H, et a .l Plant foods and he rbal sources o f resvera tro l[ J]. J Ag ric Food Chem, 2002, 50( 11): 3337- 3340.
[ 4] 侯伊玲, 薄海, 刘子泉, 等. 白藜芦醇下调线粒体 DNA修复酶对重症急性胰腺炎大鼠胰腺腺泡细胞 凋亡的影响[ J ]. 世界华人消化杂志, 2009, 17( 28) : 2892- 2898.
[ 5] Stew art J R, Artim eM C, O?? Br ian C A. Resvera tro :l A cand idate nutr itiona l substance for prostate cancer prevention[ J]. J Nutr, 2003, 133( 7): 2440- 2443.
[ 6] Filip V, PlockovaM, Sm idrkal J. Resveratro l and its antiox idant and antim icrobial effectiveness [ J] . Food Chem, 2003, 83( 4) : 585- 593.
[ 7] 程岗, 章翔, 高大宽, 等. 白藜芦醇抑制神经元MMP-9 表达的作用机制研究[ J]. 中华神经外科疾病研究 杂志, 2009, 8( 4): 312- 315.
[ 8] Sa iko P, Szakm aryA, JaegerW, et a.l Resveratro l and its ana logues: Defense against cancer, co ronary disease and neurodegenerative m a ladies or just a fad? [ J]. Mutation Research, 2008, 658( 1 /2): 68- 94.
[ 9] Lu Z, Zhang Y, L iu H, et a.l T ransport of a cancer chem opreven tive po lypheno,l resve ra tro :l Interaction w ith serum a lbum in and hem og lobin [ J]. Fluoresc, 2007, 17( 5): 580- 587.
[ 10] 陈波, 俞惠新, 谭成, 等. 碘标白藜芦醇及其小鼠体 内分布[ J ]. 原子能科学技术, 2008, 42 ( 6 ): 508- 511.
[ 11] Guengerich F P, Chun Y J, K im D, et a.l Cytochrom e P450 1B1: A targe t for inh ib ition in anticarc-i nog enesis strateg ies [ J]. M utation Research, 2003 ( 523 /524) : 73- 182.
[ 12] 李覃, 范桂香, 王伟, 等. 虎杖提取物白藜芦醇的抗 白血病作用及其可能的分子机制[ J]. 西安交通大 学学报(医学版), 2008, 29( 3): 340- 345.
[ 13] 徐万海, 乔振奎, 王晓民. 白藜芦醇诱导前列腺癌 细胞系PC-3凋亡的实验研究[ J]. 哈尔滨医科大 学学报, 2008, 42( 6) : 571- 573.

Memo

Memo:
-
Last Update: 2012-11-02