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Influence of different doses of sufentanil on anesthesia and recovery in rats

《南京理工大学学报》(自然科学版)[ISSN:1005-9830/CN:32-1397/N]

Issue:
2013年03期
Page:
0-
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Title:
Influence of different doses of sufentanil on anesthesia and recovery in rats
Author(s):
Li Jinfeng1Gao Zhao1Wang Jianmin2Chen Kuijun2Zhao Zhuo1
1.School of Mechatronical Engineering,Beijing Institute of Technology,Beijing 100081,China; 2.Institute of Surgery Research,Third Military Medical University,Chongqing 400042,China
Keywords:
sufentanil doses anesthesia recovery rats
PACS:
R915
DOI:
-
Abstract:
To compare the influence of different doses of sufentanil administrated intraperitoneally on anesthesia and recovery in rats,sixty adult SD rats are randomly divided into 5 groups(S1~S5).Rats in S1~S5 are given a single intraperitoneal injection of sufentanil 50,60,150,250 and 400 μg/kg body weight respectively.The loss of righting reflex(LRR),the duration of post-LRR ataxia and the grip time in the duration of the post-LRR ataxia are recorded,and the anesthesia depth is assessed.The data of statistics analysis show that LRR rate in S2~S5 are 100%,whereas in S1 is 83.3%.With the increase of dose administrated,the time for induction of LRR decreased,the depth of anesthesia increased,the duration of LRR and post-LRR ataxia are prolonged and the time of grip is reduced.The results demonstrate that the effect of sufentanil administrated intraperitoneally on anesthesia and recovery in rats presents dose-dependence,and sufentanil in the dose of 60~150 μg/kg provides optimal depth of anesthesia and recovery quality.

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