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Preparation and characterization of cell microcapsules based on digital injection of micro-fluidic technology


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Preparation and characterization of cell microcapsules based on digital injection of micro-fluidic technology
Li Qing12Hou Liya1Zhu Li1Zhang Weiyi1
1.School of Mechanical Engineering,NUST,Nanjing 210094,China; 2.School of Mechanical Engineering and Automation,North University of China,Taiyuan 030051,China
micro-fluids digital micro-injection cells microcapsules
Q813; R944.5
Based on the digital injection of micro-fluidic technology,cell microcapsules preparation is done to determine the changing law and control method of the cell microcapsules diameters.The mean diameter of the resultant microcapsules can reach less than 28 μm,the standard deviation is less than 5 μm,and the diameters are well monodisperse.The cell microcapsule diameter and the distribution can be conveniently changed by adjusting the driving voltage and the diameter of the micro nozzle.The survival of the cells in microcapsule is about 94%.The viability of the cells is slightly influenced by the cell microcapsulation.The prepation technology based on the digital injection of micro-fluide is suitable for the cell encapsulation.This supplies application value to deal with the cell microcapsulation automatically in the follow-up work.


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Last Update: 2014-02-28