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1,3-Dipolar cycloaddition of azides and alkynescatalyzed by copper powder(PDF)


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1,3-Dipolar cycloaddition of azides and alkynescatalyzed by copper powder
Li Guanqiong1Lin Qiuhan2
1.Patent Examination Cooperation Center of the Patent Office,State Intellectual PropertyOffice of the PRC,Guangzhou 510530,China; 2.School of Chemical Engineering,Nanjing University of Science and Technology,Nanjing 210094,China
13-dipolar cycloaddition copper powder triethylamine hydrochloride 14-disubstituted 123-triazole
The 1,3-dipolar cycloaddition of azides and alkynes efficiently catalyzed by copper powder is studied.The reaction is efficiently performed in the presence of copper powder as the catalyst and the triethylamine hydrochloride(Et3N·HCl)as the promoter in the water/t-butyl alcohol(H2O/t-BuOH)(volume ratio 1:1)under the room temperature and the normal pressure for 2 h,and the yield ratio of the 1,4-disubstituted 1,2,3-triazoles is up to 93.05%.The procedure is characterized by the lower amount of the inexpensive catalyst,the mild reaction condition,the little time-consuming,the high productivity and the easy operation.


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Last Update: 2017-04-30