[1]陆明,吕春绪,魏运洋.2,3-二羟基哌嗪与几种氨基化合物的缩合反应研究[J].南京理工大学学报(自然科学版),1998,(03):44-47.
 Lu Ming Lu Chunxu Wei Yunyang.A Study on the Condensation Reaction of 2,3-bishydroxylpiperazine with Some Amino compounds[J].Journal of Nanjing University of Science and Technology,1998,(03):44-47.
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2,3-二羟基哌嗪与几种氨基化合物的缩合反应研究()
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《南京理工大学学报》(自然科学版)[ISSN:1005-9830/CN:32-1397/N]

卷:
期数:
1998年03期
页码:
44-47
栏目:
出版日期:
1998-06-30

文章信息/Info

Title:
A Study on the Condensation Reaction of 2,3-bishydroxylpiperazine with Some Amino compounds
作者:
陆明吕春绪魏运洋
南京理工大学化工学院, 南京210094
Author(s):
Lu Ming Lu Chunxu Wei Yunyang
School of Chemical Engineering,NUST,Nanjing 210094
关键词:
缩合反应 合成 工艺 高能量密度材料 氮杂环化合物
Keywords:
condensat io n react ions synthesis technolog y hig h energ y density material azacy clo-compound
分类号:
O622.6
摘要:
由乙二胺与乙二醛的缩合物2, 3-二羟基哌嗪, 分别与甲酰胺、脲和乙二胺反应, 制得2, 4, 7, 9, 11, 14-六氮杂三环[ 8, 4, 0, 03, 8 ] 十四烷六盐酸盐四水合物( 1) , 2, 5, 7, 9-四氮杂双环[ 4, 3, 0] 壬-8-酮二盐酸盐-水合物( 2) 和2, 5, 7, 10-四氮杂双环[ 4, 4, 0] 癸烷( 3) 。化合物1 为未见文献报道的新化合物。化合物2 的合成工艺条件优化后, 反应得率与文献[ 1] 相比有一定提高。化合物3 的合成, 由于将反应分为低温和高温两个缩合阶段, 使反应得率提高到77. 5 %。
Abstract:
Hydrochlor ide of 2, 4, 7, 9, 11, 14-hexazat ricy clo [ 8, 4, 0, 03, 8 ] tet radecane( 1) and hydrochlor ide of 2, 5, 7, 9-tetr azabicycls [ 4, 3, 0] no nan-8-one( 2) and 2, 5, 7, 10-tetr azabicy clo [ 4, 4, 0] decane ( 3) w ere synthesized via r eaction of 2, 3-bishy dro xy lpiperazine that is the condensat ion product o f ethylenediamine and gly ox al w ith formamide, ur ea and ethylenediamine r espect ively . Compound 1 is a new compound that w as not r eported in liter ature. T he y ield of compound 2 is hig her than that in literature ( 1) w ith the impr ovement of react ion condit io n. T he yield o f compound 3 is as high as 77. 5%, because the condensat io n react io n of sy nthesising compound 3 is divided into low temperature and hig h temperature.

参考文献/References:

1 陆明, 魏运洋, 吕春绪. 2, 5, 7, 9-四氮杂双环[ 4, 3, 0] 壬酮-8 盐酸盐合成新工艺. 精细化工,1994, 11( 5) : 39~40
2 Nielsen AT . Chemistr y o f Energ etic Mater ials. Califo rma : Aca demic Press, 1991. 95~100
3 Vedachalam M , Rama kv ishnan V T , Boy er J H. Facile synthesis and nit ration o f cis-syn-cis-
2, 6-diox o decahydr o-1H, 5H-dimidazo [ 4, 5-b: 4′,5′-e] py razine. J Org Chem, 1991, 56: 3413~3417
4 魏运洋, 吕春绪, 陆明等. 亚甲基二硝胺的杂环化和Mannish 反应产物的合成. 应用化学. 1991, 11( 5) : 104~107
5 杨春盛. 四硝基并哌嗪的研究. 火炸药, 1984( 5) : 1~5
6 周发歧. 炸药合成化学. 北京: 国防工业出版社, 1984. 390~407

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备注/Memo

备注/Memo:
陆 明 男 36 岁 副教授
更新日期/Last Update: 2013-03-29