[1]许红霞,姜林锟,王利生.伊维菌素在醇及醇-水混合溶剂中溶解度的测定与关联[J].南京理工大学学报(自然科学版),2014,38(01):173-180.
 Xu Hongxia,Jiang Linkun,Wang Lisheng.Determination and correlation of solubilities of ivermectin in alcohol and alcohol-water mixture[J].Journal of Nanjing University of Science and Technology,2014,38(01):173-180.
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伊维菌素在醇及醇-水混合溶剂中溶解度的测定与关联
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《南京理工大学学报》(自然科学版)[ISSN:1005-9830/CN:32-1397/N]

卷:
38卷
期数:
2014年01期
页码:
173-180
栏目:
出版日期:
2014-02-28

文章信息/Info

Title:
Determination and correlation of solubilities of ivermectin in alcohol and alcohol-water mixture
作者:
许红霞1姜林锟12王利生2
1.内蒙古工业大学 乌海学院,内蒙古 乌海 016000; 2.北京理工大学 化工与环境学院,北京 100081
Author(s):
Xu Hongxia1Jiang Linkun12Wang Lisheng2
1.Wuhai Institute,Inner Mongolia University of Technology Wuhai 016000,China; 2.School of Chemical Engineering and Environment,Beijing Institute of Technology,Beijing 100081,China
关键词:
伊维菌素 溶解度 平衡法 模型关联 Apelblat方程
Keywords:
ivermectin solubilities equilibrium method correlation Apelblat equation
分类号:
O645.2
摘要:
为了优化阿维菌素催化加氢制备伊维菌素的工艺条件,对伊维菌素的溶解度进行了研究。该文采用平衡法测定了293.15~333.15 K时,伊维菌素在甲醇、乙醇以及不同比例的甲醇-水和乙醇-水混合体系中的溶解度,并对实验结果采用多项式经验方程、理想溶液模型和Apelblat方程模型进行了关联。结果表明:伊维菌素在这两种醇-水溶液体系中的溶解度均随温度的升高而增大; 相同温度下,伊维菌素在甲醇-水溶剂体系中溶解度随水含量的增大而下降,而在乙醇-水溶剂体系中溶解度在85%乙醇水溶液中达到最大,在纯乙醇中溶解度反而减小。用三种方程模型计算的理论溶解度与实验值吻合良好,相关性均>0.98,其中,Apelblat模型的相关性数值较大,关联结果最好。实验得到的溶解度数据和关联结果对伊维菌素结晶工艺的研究具有较大的指导意义。
Abstract:
In order to provide basic data of solvent selection and temperature control of purification in catalytic hydrogenation of avermectin to ivermectin process,the solubilities of ivermectin in methanol(293.15~333.15 K),alcohol(293.15~343.15 K),water-methanol mixture(293.15~333.15 K),and water-alcohol mixture(293.15~343.15 K)are experimentally determined by the equilibrium method.The experimental results are correlated with mathematic models such as polynomial empirical equation,the ideal solution equation,and Apelblat equation,respectively.The results show that the solubilities of ivermectin in two alcohol-water systems increase with the temperature; the solubility of ivermectin in the methanol-water solvent system decreases with the the increase of water content at the same temperature,and in the ethanol-water solvent system,the solubility of ivermectin in 85% ethanol solution reaches a maximum.Each of the equations describes the above systems successfully,the correlation coefficients are above 98%.The Apelblat equation is the best to correlate the solubility data.Results of experiments and correlations can be used for the crystallization procedure of ivermectin production.

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备注/Memo

备注/Memo:
收稿日期:2013-02-28 修回日期:2013-09-09
基金项目:内蒙古自治区自然科学基金(NJC11311); 中央财政支持重点建设项目(530201)
作者简介:许红霞(1972-),女,副教授,主要研究方向:分离提纯; E-mail:xhx72@sohu.com。
引文格式:许红霞,姜林锟,王利生.伊维菌素在醇及醇-水混合溶剂中溶解度的测定与关联[J].南京理工大学学报,2014,38(1):173-180.
投稿网址:http://njlgdxxb.paperonce.org
更新日期/Last Update: 2014-02-28