[1]崔家旗,许 颖,阮子静,等.某院金黄色葡萄球菌的临床分布及耐药性分析[J].南京理工大学学报(自然科学版),2019,43(06):793-797.[doi:10.14177/j.cnki.32-1397n.2019.43.06.018]
 Cui Jiaqi,Xu Ying,Ruan Zijing,et al.Clinical distribution and drug resistance analysis ofStaphylococcus aureus in a teaching hospital[J].Journal of Nanjing University of Science and Technology,2019,43(06):793-797.[doi:10.14177/j.cnki.32-1397n.2019.43.06.018]
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某院金黄色葡萄球菌的临床分布及耐药性分析()
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《南京理工大学学报》(自然科学版)[ISSN:1005-9830/CN:32-1397/N]

卷:
43卷
期数:
2019年06期
页码:
793-797
栏目:
出版日期:
2019-12-31

文章信息/Info

Title:
Clinical distribution and drug resistance analysis ofStaphylococcus aureus in a teaching hospital
文章编号:
1005-9830(2019)06-0793-07
作者:
崔家旗1许 颖2阮子静3朱小奎4黄新河3贾 旭1
1.成都医学院 非编码RNA与药物四川省高校重点实验室,四川 成都 610500; 2.成都医学院第一附属医院 检验科,四川 成都 610500; 3.西南交通大学 生命科学与工程学院,四川 成都 610031; 4.遵义医科大学 生物化学与分子生物学教研室,贵州 遵义 563000
Author(s):
Cui Jiaqi1Xu Ying2Ruan Zijing3Zhu Xiaokui4Huang Xinhe3Jia Xu1
1.Non-coding RNA and Drug Discovery Key Laboratory of Sichuan Province,Chengdu Medical College,Chengdu 610500,China; 2.Clinical Laboratory,the First Affiliated Hospital of Chengdu Medical College,Chengdu 610500,China; 3.School of Life Sciences and Engi
关键词:
金黄色葡萄球菌 耐甲氧西林金黄色葡萄球菌 临床分布 耐药性 青霉素 红霉素 克林霉素
Keywords:
Staphylococcus aureus methicillin-resistant S.aureus clinical distribution drug resistance penicillin erythromycin clindamycin
分类号:
R378
DOI:
10.14177/j.cnki.32-1397n.2019.43.06.018
摘要:
为研究金黄色葡萄球菌(Staphylococcus aureus,S.aureus)在医院的临床分布特征及耐药情况,该文以四川某医院2018年收集的539株S.aureus为研究对象,采用微量肉汤稀释法测定其对15种抗生素的最低抑菌浓度(MIC),并用统计学方法进行分析。结果显示,539株S.aureus中有142株耐甲氧西林金黄色葡萄球菌(Methicillin-resistant Staphylococcus aureus,MRSA); MRSA主要分布于皮肤性病科(30株,21.1%); S.aureus对青霉素、红霉素、克林霉素耐药率较高,分别为96.10%、63.50%、60.30%,但对利奈唑胺、万古霉素等敏感; MRSA菌株对苯唑西林、青霉素、红霉素等的耐药率均明显高于甲氧西林敏感型金黄色葡萄球菌(Methicillin-sensitive Staphylococcus aureus,MSSA)菌株; 在预防和治疗S.aureus感染时,需根据药敏实验合理选择使用抗菌药物。
Abstract:
To investigate the clinical distribution and drug resistance of Staphylococcus aureus(S.aureus)in a hospital,a total of 539 strains of clinical isolated S.aureus are collected from a hospital in 2018 in Sichuan Province,and the minimum inhibitory concentration(MIC)of 15 antibiotics for the S.aureus is determined by broth microdilution method and analyzed by statistical method. The results show that there are 142 strains of methicillin-resistant Staphylococcus aureus(MRSA)among 539 S.aureus isolates; 142 MRSA are mainly distributed in dermatology(30 strains,21.1%); the drug resistance rates of 539 S.aureus isolates to penicillin,erythromycin,clindamycin are relatively high,such as 96.10%,63.50%,60.30% respectively,but 539 S.aureus isolates are sensitive to linezolid,vancomycin and some other drugs; the resistance rates of MRSA strains to benzacillin,penicillin,erythromycin and some other drugs are higher than those of methicillin-sensitive Staphylococcus aureus(MSSA)strains; in the prevention and treatment of S.aureus infection,hospitals should reasonably choose antimicrobial agents according to the drug sensitivity test.

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备注/Memo

备注/Memo:
收稿日期:2019-08-05 修回日期:2019-10-10
基金项目:国家自然科学基金(31870135)
作者简介:崔家旗(1992-),男,硕士生,主要研究方向:细菌耐药机制,E-mail:303229209@qq.com; 通讯作者:贾旭(1981-),男,博士,教授,主要研究方向:细菌耐药机制,E-mail:jiaxu@cmc.edu.cn。
引文格式:崔家旗,许颖,阮子静,等. 某院金黄色葡萄球菌的临床分布及耐药性分析[J]. 南京理工大学学报,2019,43(6):793-799.
投稿网址:http://zrxuebao.njust.edu.cn
更新日期/Last Update: 2019-12-31